Two pedigrees with restless legs syndrome in Brazil.
نویسندگان
چکیده
Numerous studies have suggested a substantial genetic contribution in the etiology of the primary form of restless legs syndrome (RLS) and periodic leg movements (PLM). We describe the symptoms, the sleep profiles and physiological parameters of two families in which several members present RLS/PLM. The proband of family 1 is a 70-year-old woman and the proband of family 2 is a 57-year-old woman; both have exhibited the symptoms since the age of 20 years. All patients in both families were diagnosed with RLS according to the criteria of the International RLS Study Group. Polysomnographic recordings were performed to quantify and to describe PLM during sleep. Sleep parameters showed decreased sleep efficiency, increased sleep latency in the arousal index and the presence of PLM in all subjects. One of the families showed an exact profile of dominant inheritance with anticipation of age at onset. In the other family, the founders were blood relatives and there was no affected member in the third generation suggesting a recessive mode of inheritance. RLS/PLM is a prevalent sleep disorder affecting about 5 to 15% of the population and one that substantially impairs healthy sleep patterns. Efforts to understand the underlying pathophysiology will contribute to improve the sleep and life quality of these patients.
منابع مشابه
Methods of Controlling Restless Legs Syndrome in Diabetic Patients: A Scoping Review Study
Introduction: ‘Restless Legs Syndrome’ is a sensory-motor disorder manifested by a tendency to move legs, usually accompanied by discomfort in the legs. Studies have shown that diabetics are more at risk for Restless Legs Syndrome than the general population. Therefore, a review study was designed to determine the methods of controlling restless legs syndrome in patients with diabetes. Methods:...
متن کاملرابطه کمبود آهن و سندرم پاهای بیقرار در بیماران تحت همودیالیز
Introduction: Restless legs syndrome is a neurological disorder hemodialysis patients seem to suffer more from this syndrome. Although the pathophysiology of restless legs syndrome is still unknown, assessment of factors associated with this syndrome can help to develop medical knowledge in this field. The present study assessed the relationship between restless legs syndrome, serum iron, and s...
متن کاملPrevalence of Restless Legs Syndrome in Iranian Patients under Hemodialysis: A Systematic Review and Meta-Analysis Study
Introduction: Recent studies have contradictory reports of the overall prevalence of restless legs syndrome in hemodialysis patients. Therefore, the aim of this study was to help eliminate ambiguity about the prevalence of restless legs syndrome in Iranian hemodialysis patients by systematic review and meta-analysis study. Methods: This study was performed based on PRISMA checklist. Documents ...
متن کاملRestless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity.
BACKGROUND Genes are involved in the etiology of restless legs syndrome, a common sensorimotor disorder. OBJECTIVES To replicate and to further characterize our previously reported chromosome 12q linkage results. DESIGN Family linkage study. SETTING AND PARTICIPANTS A total of 276 individuals from 19 families have been examined using a selection of markers spanning the identified candidat...
متن کاملThe Prevalence of Restless Legs Syndrome in Patients Undergoing Hemodialysis: A Systematic Review and Meta-analysis Study
Introduction: Restless legs syndrome is a sensory-motor disorder that causes sleep disorder. The syndrome in patients undergoing hemodialysis has to do with depression, sleep deprivation, performance disorder, day fatigue, excessive daytime sleepiness, stress and anxiety, and increased risk of cardiovascular diseases. The objective of this systematic meta-analysis study was to estimate prevalen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
دوره 41 2 شماره
صفحات -
تاریخ انتشار 2008